GABA content and an antioxidant profile positively correlated with the anticonvulsive activity of Microcos paniculata in acute seizure mice

This study evaluated the effects of different parts M. paniculata (MP) extracts on convulsions and antioxidant activities in mice. Six polyphenolic compounds were identified, where epicatechin quercetin have been identified highest amounts (23.01 32.23 mg/100 g dry MP extract, respectively) leaf stem extracts, using Ultra Performance Liquid Chromatography. 7-day oral administration at doses 100, 200, 400 mg/kg body weight (BW) significantly reduced mortality rates compared with seizure inducer groups. Antioxidant potentials measured by superoxide dismutase (SOD), catalase (CAT), thiobarbituric acid reactive substances (TBARS), glutathione (GSH) content whole-brain homogenates. Gamma-aminobutyric (GABA) levels increased leaves stem-treated groups, suggesting that stems potent properties can attenuate modulating GABAergic system activities.